We’re in the era of safe, effective testosterone replacement therapy (TRT). The only big hurdle left is making sure enough men know what’s possible in the golden era of hormone replacement. In the past, options for men with low testosterone were limited. All of the reasons that may have caused men to overlook TRT in the past to manage symptoms of low testosterone have essentially been wiped away with the arrival of new delivery methods and long-acting formulations. One especially exciting new development is the arrival of undecanoate-style TRT on the market. This treatment is an androgen and anabolic steroid (AAS) medication that can be taken orally or injected into muscle to help balance hormones. Here’s why it’s promising:
- Undecanoate-based treatments gained approval by the U.S. Food and Drug Administration in 2019.
- In studies, this is an effective long-term treatment for men with low testosterone levels with no evidence of liver toxicity.
- An 11-year-long-term study found that injectable undecanoate-based treatments produced significant reductions in weight, waist circumference, and body mass index (BMI) in hypogonadal men.
If you’re one of the millions of men in the United States suffering from fatigue, weight gain, and reduced libido that are signatures of low T, there’s a lot you need to know about what the next few years of your life can look like.
The Evolution of Testosterone Replacement Therapy: Good Just Got Better
If we’re honest, early TRT treatments were a bit clunky. Men seeking to boost their testosterone levels had no choice other than to visit clinics for frequent injections. While testosterone replacement therapies were undoubtedly groundbreaking and life-changing for millions of men, results were limited by poor absorption, short duration of action, and other factors.
It’s a different experience for men seeking treatment for low T today. For example, the aforementioned undecanoate-style TRT now makes both oral and long-acting injectable options possible. That means that TRT is now so much more convenient and accessible for patients around the country who don’t have the time for frequent office visits.
More on Undecanoate
Injectable undecanoate-based treatment blows former TRT duration periods out of the water. In the past, men seeking to boost T levels were required to visit clinics for injections every one to two weeks. For men who choose long-lasting injectables, injections are spaced between 10 and 12 weeks apart. That doesn’t just provide the benefit of fewer clinic visits. That longevity also results in much more stable hormone levels during maintenance periods.
How Can Men Get the Newest Testosterone Replacement Therapy?
Undecanoate-style TRT is primarily prescribed for testosterone replacement therapy for men with confirmed testosterone deficiency. Like traditional testosterone therapies, undecanoate-based treatment helps to balance T levels to undo symptoms of low T that can include weight gain, brain fog, mood changes, irritability, low muscle mass, and low libido.

Undecanoate-based treatments can help to restore masculine characteristics, support muscle and bone health, and improve mood and sexual function. To safely and effectively use any type of FDA-approved low-T treatment, it’s essential to work with a board-certified doctor specializing in hormone imbalances.
Fixing Low Testosterone Is Within Reach for More Men Than Ever Before
Many men who simply don’t “feel like they used to” are struggling with dipping testosterone levels.

Testosterone levels generally drop for all men after age 30. Factors that include lifestyle, diet, stress levels, and genetics can all contribute to earlier or more severe T declines. While there are some natural ways to boost testosterone levels using good diet and exercise practices, a T imbalance or deficiency will not correct itself on its own. Talk with an expert!



